Assessment of prognostic Significance of some Blood proteins in Diagnosing Liver Cirrhosis Among Patients with Chronic Liver Disease

Document Type : Original Article

Authors

1 Biochemistry- faculty of science- mansoura university - mansoura-Dakahlia

2 Prof of General Surgery - faculty of medicine- mansoura university -Dakahlia

3 Fellow of medical analyses Gisc – Masnsoura university

4 prof of biochemistry -Gisc – Masnsoura university - mansoura-Dakahlia

Abstract

Chronic liver disease (CLD) and liver cirrhosis are two critical worldwide health problems that raise morbidity and death rates. The last stage of liver disease, cirrhosis is characterized by the replacement of healthy liver tissue with fibrotic scar tissue, which impairs liver function and causes complications like variceal bleeding, portal hypertension, ascites, and hepatic encephalopathy. The primary causes of cirrhosis are autoimmune liver diseases, nonalcoholic fatty liver disease (NAFLD), chronic viral hepatitis, and excessive alcohol use. The current study has a number of advantages and impacts It examined the most recent developments in the clinical, laboratory, and diagnostic features of liver cirrhosis patients, affording insights into the course of the medical condition and possible biomarkers for its detection and treatment. Usually, this disease progresses gradually over several months or years. The entire body is responding to the damaged liver, including the skin, brain, kidneys, gastrointestinal tract, immune system, bone marrow, heart, etc. In order to help with early diagnosis and save more lives, the current study concentrated on the most recent developments in blood-based diagnostic biomarkers to assess the diagnostic power of Mac-2 binding protein glycosylation isomer (M2BPGi) and determine the cut-off values of M2BPGi for liver cirrhosis in patients with chronic liver disease.

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