Biosynthesis of Propolis-silver nanoparticles: Optimization and In Vitro Validation for antimicrobial applications

Document Type : Original Article

Authors

1 Chemistry department Mansoura University

2 Chemistry, fuculty of science Mansoura University

3 Polymers and Pigments Department National Research center

4 Chemistry department fuculty of science Mansoura University

Abstract

There is a current research focus on producing bioactive nanomaterials through

eco-friendly approaches because of the wide range of uses for these materials in

different industries. In this study, a simple and environmentally conscious

chemistry approach was utilized to produce silver nanoparticles (AgNPs) using

Egyptian propolis as the reducing and capping agent. The resulting silver

nanoparticles were characterized using several methods, including UV

spectroscopy and TEM. The dimensions of the synthesized silver nanoparticles

measured 4.5 ± 1 nm, increasing to 11 ± 4 nm with higher concentrations of silver

nitrate. The antimicrobial properties of PP samples, enhanced by varying

concentrations of Ag-NPs, effectively inhibit Escherichia coli, Streptococcus mutans,

and Candida albicans. Moreover, high MIC values were observed among all

samples against Escherichia coli. The antimicrobial activity increases with the

increase of Ag-NPs concentration in the PP extracts. These results demonstrate the

potential of the Ag-PP sample as an effective antimicrobial agent to combat against

bacterial infection.

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