Evaluation the role of some biomarkers in Egyptian women with breast cancer

Document Type : Original Article

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Abstract

Breast cancer (BC) is the primary prevalent malignancy among women globally. Currently, it is now recognized that evasion of cell death is a hallmark of cancer. Bcl-2 gene is involved in the mechanism of cell survival and prolongs cell life by preventing apoptosis through activation of various signaling pathways. Aim: We aimed to evaluate whether Bcl-2 is correlated with BC among Egyptian women, and its association with clinical and pathological characteristics of the disease. Method: This study was designed to include 200 women including 100 breast cancer patients and 100 unrelated women without cancer . Blood samples were aspirated from all the participants and serum CA15.3, CEA and Bcl-2 levels were measured using ELISA technique. Results: The results obtained displayed that the serum levels of CA15.3, CEA and Bcl-2 were significantly associated with an increased risk of breast cancer compared to the healthy group (P < 0.001 for all). Conclusions: The serum levels of  CA15.3, CEA and Bcl-2 are correlated with an breast carcinoma among Egyptian women.

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