In the present study, 2-amino-4-methyl-5-(pyridin-2-ylcarbamoyl)thiophene-3-ethylcarboxylate (2) has been achieved using Gewald’s methodology between 3-oxo-N-(pyridin-2-yl)butanamide (1), ethyl 2-cyanoacetate and elemental sulfur in refluxing ethyl alcohol containing a catalytic amount of morpholine. This 2-aminothiophene derivative was served as key synthon for the synthesis of new thiazolidin-4-one, chromen-2-imine and pyrrol-2-one derivatives via its reactions with the convenient chemical reagents. The mechanistic aspects for the achievement of the new thiophene derivatives were also discussed
Mekabaty, A., . Fouda, A. S., & . I. Shaaban, I. E. (2019). Convenient synthesis of some new thiazolidin-4-one, chromen-2-imine and pyrrol-2-one derivatives containing thiophene moiety. Mansoura Journal of Chemistry, 46(4), 7-11. doi: 10.21608/mjcc.2019.413044
MLA
Ahmed Mekabaty; A. S . Fouda; Ibrahim E . I. Shaaban. "Convenient synthesis of some new thiazolidin-4-one, chromen-2-imine and pyrrol-2-one derivatives containing thiophene moiety", Mansoura Journal of Chemistry, 46, 4, 2019, 7-11. doi: 10.21608/mjcc.2019.413044
HARVARD
Mekabaty, A., . Fouda, A. S., . I. Shaaban, I. E. (2019). 'Convenient synthesis of some new thiazolidin-4-one, chromen-2-imine and pyrrol-2-one derivatives containing thiophene moiety', Mansoura Journal of Chemistry, 46(4), pp. 7-11. doi: 10.21608/mjcc.2019.413044
VANCOUVER
Mekabaty, A., . Fouda, A. S., . I. Shaaban, I. E. Convenient synthesis of some new thiazolidin-4-one, chromen-2-imine and pyrrol-2-one derivatives containing thiophene moiety. Mansoura Journal of Chemistry, 2019; 46(4): 7-11. doi: 10.21608/mjcc.2019.413044
)
View on SCiNiTO