The chlorine atom of 2-chloronicotinonitrile derivative 2 has been substituted via its heating with ethyl 4-aminobenzoate to give the conforming ethyl 4-(3-cyano-pyridin-2-ylamino)benzoate scaffold 3, which underwent refluxing with hydrazine hydrate to produce the hydrazide derivative 4. The reaction of hydrazide 4 withethyl acetoacetate furnished the corresponding 2-((4-(3-methyl-5-oxo-1H-pyrazole-1-carbonyl)phenyl)-amino)nicotinonitrile derivative 6 which reacted with phenyl isothiocyanate and chloroacetone, phenacyl chloride or ethyl bromoacetate to give the corresponding 2-((4-(4-(3-phenylthiazolylidene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazole-1-carbonyl)-phenyl)amino)-4,6-dimethyl-nicotinonitriles 10a, 10b and 11. In general, all synthesized pyridine scaffolds revealed better activity against the Gram-positive bacterium (B. subtilis) rather than the Gram-negative bacterium (E. coli).
Abdel-Latif, E., Berghot, M. A., Abdel-Galil, E., & Zaki, A. I. (2020). Synthesis and antibacterial survey of some nicotinonitriles clubbed with pyrazolone and/or thiazole. Mansoura Journal of Chemistry, 44(2), 1-7. doi: 10.21608/mjcc.2020.412969
MLA
Ehab Abdel-Latif; Moged A. Berghot; Ebrahim Abdel-Galil; Alshimaa I. Zaki. "Synthesis and antibacterial survey of some nicotinonitriles clubbed with pyrazolone and/or thiazole", Mansoura Journal of Chemistry, 44, 2, 2020, 1-7. doi: 10.21608/mjcc.2020.412969
HARVARD
Abdel-Latif, E., Berghot, M. A., Abdel-Galil, E., Zaki, A. I. (2020). 'Synthesis and antibacterial survey of some nicotinonitriles clubbed with pyrazolone and/or thiazole', Mansoura Journal of Chemistry, 44(2), pp. 1-7. doi: 10.21608/mjcc.2020.412969
VANCOUVER
Abdel-Latif, E., Berghot, M. A., Abdel-Galil, E., Zaki, A. I. Synthesis and antibacterial survey of some nicotinonitriles clubbed with pyrazolone and/or thiazole. Mansoura Journal of Chemistry, 2020; 44(2): 1-7. doi: 10.21608/mjcc.2020.412969
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