Short Telomeres and Survival Rate in Bone Marrow Failure Disease

Document Type : Original Article

Authors

1 Chemistry Department, Biochemistry Division, Faculty of Science, Mansoura University, Egypt

2 Clinical Pathology Department, Faculty of Medicine, Mansoura University, Egypt.

3 Pediatric Department, Children's Hospital, Faculty of Medicine, Mansoura University, Egypt

4 Oncology Center, Faculty of Medicine, Mansoura University, Egypt.

5 Clinical Pathology Department, Faculty of Medicine, Mansoura University, Egypt

Abstract

Bone marrow failure (BMF) syndromes include inherited and acquired conditions. Inherited bone marrow failure includes a number of syndromes; with Fanconi anemia (FA) being the most common one of them. Telomeres became shorter with each cell division, but in hematopoietic stem cell, maintenance of their length is mediated by telomerase. Short telomeres lead to instability of cell function where diseases occur. BMF might be developed as a result of low telomerase activity or short telomeres. So, our study aims to assess the relative telomere length (RTL) and its correlation with gender of the Egyptian patients with BMF syndromes for overall survival and patient's current situation. The study included 39 BMF patients and 15 individuals as a healthy control group. The RTL is evaluated for them using Real-Time Quantitative-Polymerase Chain Reaction (RQ-PCR) technique. We observed that there was no difference in the RTL between males and females (P-value= 0.921). Kaplan–Meier survival analysis showed that there was no difference in the survival rate of BMF patients (P-value=0.695). We conclude that the death or mortality rate is not associated with short telomeres in BMF patients either in males or females.

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