Fabrication AND INVESTIGATION OF BICHALCOPHENES-LOADED POLYMERS

Document Type : Original Article

Authors

Chemistry Department, Faculty of Science, Mansoura University, ET-35516-Mansoura, Egypt

Abstract

Controlled release formations of drugs were prepared from bichalcophene derivatives as drugs and sodium carboxymethylcellulose (NaCMC) as a matrix of natural polysaccharide. The release behavior of bichalcophene derivatives from the NaCMC matrix was studied. The solubility and chemical nature of these derivatives have a significant effect on their release characteristics. The current study showed that the cationic amidinic bichalcophene derivatives exhibit a slow release rate due to the formation of hydrogen bonds between their positively charged amino groups and the negatively charged carboxyl groups of the polymer matrix. The derivatives of poor solubility exhibit a slow release rate while soluble derivatives show a fast release rate

Keywords

Mansoura Journal of Chemistry
Volume 51, Issue 1
February 2021
Pages 26-32

Files

Share

How to cite

Statistics