Assessment of Oxidative Stress in Pediatric Sepsis

Document Type : Original Article

Authors

1 Biochemistry Division, Chemistry Department Faculty of Science, Mansoura University, Mansoura, Egypt

2 Children Hospital (MUCH), Faculty of Medicine, Mansoura University Mansoura, Egypt

Abstract

Background: Sepsis is at present one of the leading causes of morbidity and mortality in the children population. We performed this study to evaluate the levels of certain antioxidants in the blood of children with sepsis. Methods: Study group had 48 children with sepsis (0.3 ±11 years) and 20 age -matched healthy controls admitted to Pediatric intensive care unit (pICU) at Mansoura University Children Hospital (MUCH), Mansoura, Egypt. Interleukin 6 (IL6), Malondialdehyde (MDA), Catalase (CAT), superoxide dismutase (SOD) and Glutathione (GSH) by standard techniques. Results: There was significant elevation in the level of IL6 and MDA in sepsis and correlated with the severity of sepsis when compared to controls. However, GSH level was significantly reduced in septic patients compared to healthy control cases. While, no significant changes in the activity of SOD and CAT in patient compared to healthy cases. Catalase was significantly and positively correlated to glutathione and superoxide dismutase. MDA was significantly but negatively correlated to serum catalase, SOD and GSH levels in the studied septic children. Sepsis severity was significantly but negatively correlated to serum glutathione level. Conclusion: Our observations show that the toxicity of free radical induced by sepsis affected on pediatric patients by sepsis probably adapt to. These results may be due to the adaptive response of the body to compensate the oxidative stress and active phagocytosis

Keywords

Mansoura Journal of Chemistry
Volume 51, Issue 1
February 2021
Pages 19-25

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