Biochemical and Molecular studies on the role of Androgens in the Pathogenesis of renal calcium stones

Shamshoun, Heba; Shokeir, Ahmed A.; Elshal, Ahmed M.; El-Khawaga, Omali Y.

doi:10.21608/mjcc.2022.412166

Biochemical and Molecular studies on the role of Androgens in the Pathogenesis of renal calcium stones

Document Type : Original Article

Authors

¹ Faculty of science, Chemistry department, Biochemistry division, Mansoura university

² Professor of urology, Urology& nephrology center, Mansoura University.

³ Assistant prof. of urology, Urology& nephrology center, Faculty of Medicine, Mansoura University

⁴ Prof. of Biochemistry, Faculty of science, Mansoura University

10.21608/mjcc.2022.412166

Abstract

Although kidney stone disease has been recognized by the medical community, the mechanisms behind stone development and formation are still largely unclear. The recent technological developments have been applied in the surgical management of kidney stones.
The goal of the current research is to understand how androgens contribute to the development of renal calcium stones.
In this prospective, controlled trial and Egyptian male patients between the ages of 18 and 60 are included. All clinical data was collected including history, clinical examination, and standard laboratory testing. The hormones testosterone (T), free testosterone (FT), and dihydrotestosterone (DHT) were detected in plasma samples using immunoassay is an analytical technique.
Following a diagnosis of renal stones, 23 patients were included in the trial between June 2020 and June 2021. They were hospitalized for endoscopic treatment with PNL (percutaneous nephrolithotomy) or RIRS (retrograde intrarenal surgery), and their outcomes were compared to 23 controls. The control group's mean age was 60.2±6.1, while the SFG group' s was 54±10.3
There was a noticeable difference between the control group and the stone patients in terms of blood testosterone, free testosterone, and dihydrotestosterone. Male kidney stone patients considerably exhibited greater serum testosterone concentrations than age-matched stone-free people, according to the results of the ELISA test. Male kidney stone patients exhibited greater serum testosterone concentrations than age-matched stone-free people.
In conclusion, Increasing sex hormone levels were positively connected with CaOx(Calcium Oxalate) renal stones..

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