Objective: This study aimed at exploring the therapeutic efficacy of L-Carnitine (LC) against cisplatin-induced nephrotoxicity (CIN) by assessing oxidative stress response, and relevant gene expression in rat kidney tissues. Methods: Rat CIN model was induced by intraperitoneal injection of Cisplatin (Cis). Eighteen male Sprague-Dawley mature rats with age (6 weeks) weighing 180 ± 20 gm were randomized to receive either control (saline), Cis or Cis + LC. Markers of oxidative stress (superoxide dismutase (SOD) and Malonaldehyde (MDA) and Bax and BCL-2 gene expression profiles were assessed thereafter. Results: Cisplatin administration showed a marked increase in oxidative stress as evidenced by elevated MDA and diminished SOD levels, and changes in gene expressions of apoptosis-regulating genes (BCL2, BAX). Remarkably, treatment with LC normalized most parameters and achieving gene expression levels comparable to control groups. Conclusion: Our findings highlight the significant nephroprotective potential of LC against CIN, pivoting the way for bigger clinical studies and incorporation into clinical care guidelines.
Majid, M., Awadalla, A., Youssef, M. M., & Shokeir, A. (2023). L-carnitine promising effects in cisplatin-induced nephrotoxicity. Mansoura Journal of Chemistry, 59(1), 46-50. doi: 10.21608/mjcc.2023.411529
MLA
Maria Majid; Amira Awadalla; Magdy M. Youssef; Ahmed Shokeir. "L-carnitine promising effects in cisplatin-induced nephrotoxicity", Mansoura Journal of Chemistry, 59, 1, 2023, 46-50. doi: 10.21608/mjcc.2023.411529
HARVARD
Majid, M., Awadalla, A., Youssef, M. M., Shokeir, A. (2023). 'L-carnitine promising effects in cisplatin-induced nephrotoxicity', Mansoura Journal of Chemistry, 59(1), pp. 46-50. doi: 10.21608/mjcc.2023.411529
VANCOUVER
Majid, M., Awadalla, A., Youssef, M. M., Shokeir, A. L-carnitine promising effects in cisplatin-induced nephrotoxicity. Mansoura Journal of Chemistry, 2023; 59(1): 46-50. doi: 10.21608/mjcc.2023.411529
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