Effect of Chromium and Cadmium on Genetic and Oxidative Stress mechanisms in Bladder Cancer Patients

Document Type : Original Article

Authors

1 Department of Chemistry, Biochemistry division, Faculty of Science, Mansoura University, Egypt

2 Center of Excellence for Genome and Cancer Research, Urology and Nephrology Center, Mansoura University, Mansoura 35516, Egypt

3 Clinical Chemistry Laboratory, Urology and Nephrology Center, Mansoura University,Mansoura 35516, Egypt

Abstract

Background: Heavy metals toxicity has been linked to cancer progression. The relation between some metal ions and bladder cancer (BC) has been elucidated in previous studies. But the influence of these metals on bladder carcinogenesis still needs further study.
Methods and results: This study includes25 BC patients. Chromium and cadmium levels, markers of oxidative stress and m-RNA of IL-6 and Bax were detected in tissues obtained from BC patients. Cr and Cd levels were highly expressed in tumor tissues than normal. The concentration of Malondialdehyde (MDA) was highly detected in tumor tissues, while Superoxide dismutase (SOD) level was lower. IL-6 was up-regulated in tumor tissues than in normal tissues while Bax level was down regulated in tumor tissue. In cancer tissue, there were significant correlations between Cd level with Bax (Bcl-2 Associated X-protein) and IL-6 gene expression.
Conclusions: The correlation between Cd and Bax and IL-6 gene expression may indicate the carcinogenic role of Cd in bladder cancer patients

Keywords

Mansoura Journal of Chemistry
Volume 59, Issue 1
January 2023
Pages 19-24

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