CONVENIENT SYNTHESIS OF SOME NEW THIAZOLIDIN-4-ONE, CHROMEN-2-IMINE AND PYRROL-2-ONE DERIVATIVES CONTAINING FURAN MOIETY

Document Type : Original Article

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1 Chemistry Department, Faculty of Science, Mansoura University, El-Gomhoria Street, ET-35516 Mansoura, Egypt.

2 Chemistry Department, Faculty of Science, Mansoura University

Abstract

The attending work used Gewald's approach to produce ethyl 2-amino-4,5-diphenylfuran-3-carboxylate (2) by condensing benzoin (1) with ethyl cyanoacetate while stirring in dimethylformamide containing a catalytic amount of diethylamine. Through its interactions with practical chemical reagents, this 2-aminofuran derivative worked as a crucial synthon for the synthesis of novel thiazolidin-4-one, chromen-2-imine, and pyrrol-2-one derivatives. It was also addressed how the novel furan derivatives were achieved mechanistically

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