Association between Urea levels and Gradual Renal Function Decline in Children Afflicted with Chronic Kidney Diseases

Document Type : Original Article

Authors

1 Biochemistry division, Chemistry department, Faculty of Science, Mansoura University.

2 Pediatrics department, Faculty of Medicine, Mansoura University

3 Children`s Hospital, Faculty of Medicine- Mansoura University

4 Chemistry department, Faculty of Science, Mansoura University

Abstract

Chronic kidney disease (CKD) poses a significant health challenge in the paediatric population, leading to enduring adverse effects on affected individuals' well-being. The heightened mortality and morbidity rates associated with CKD. Accumulation of urea as a result of impaired renal function may induce kidney damage and accelerate CKD progression. Therefore, we measured the concentration of creatinine and urea to study the correlation between the progressive decline in renal function and urea levels in blood samples within our study cohort of 5 groups of paediatric CKD patients (stages 1 to 5) in order to understand the relation between uremia and compromised renal function and improve the quality of life for children grappling with CKD. Our findings indicated a significant positive correlation between creatinine and urea levels in our study group of children with CKD

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